Involvement of p38 in campthothecin induced expression of UCP2 in rat neonatal cardiomyocytes

0321664 - FGÚ 2009 NL eng A - Abstract
Valoušková, E. - Vostálová, J. - Ježek, Petr - Modrianský, M.
Involvement of p38 in campthothecin induced expression of UCP2 in rat neonatal cardiomyocytes.
[Úloha p38 v kampthothecinem indukované expresi UCP2 v potkaních neonatálních myocytech.]
Biochimica Et Biophysica Acta-Bioenergetics. Elsevier. Roč. 1777, Suppl. (2008), S63-S64. ISSN 0005-2728. E-ISSN 1879-2650.
[European Bioenergetics Conference /15./. 19.07.2008-24.07.2008, Dublin]
R&D Projects: GA ČR GA303/08/0658
Institutional research plan: CEZ:AV0Z50110509
Keywords : cpo1 * UCP2 * p38 * cardiomyocytes
Subject RIV: CE - Biochemistry

Campthothecin (CPT, a topoisomerase I inhibitor) induces UCP2 expression on both mRNA and protein level in cardiomyocytes. Our results suggest that activation of p38MAPK-regulated signaling cascade leads to increased expression of UCP2 in cardiomyocytes, offering a protecive mechanism against CPT-related apoptosis

Kampthothecin (CPT, inhibitor Topoizomerázy I) indukuje expresi UCP2 jak na úrovni mRNA, tak na úrovni proteinu. Naše výsledky naznačují, že aktivací kaskády regulované p38MAPK se aktivuje ochranný mechanismus proti apoptóze způsobené CPT
Permanent Link: http://hdl.handle.net/11104/0170135