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The mechanisms regulating cytochrome P450 1B1 expression and their importance for metabolic activation of promutagens

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    0320266 - BFÚ 2009 CZ eng A - Abstract
    Vondráček, Jan - Umannová, Lenka - Kozubík, Alois - Machala, M.
    The mechanisms regulating cytochrome P450 1B1 expression and their importance for metabolic activation of promutagens.
    [Mechanismy regulace exprese cytochromu P450 1B1 a jejich význam pro metabolickou aktivaci promutagenů.]
    Collection of Abstracts. Praha, 2008. S125-S126. ISSN 1214-6994.
    [58th Pharmacological Days. 03.09.2008-05.09.2008, Praha]
    R&D Projects: GA ČR(CZ) GA524/06/0517
    Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
    Keywords : CYP1B1 * polyaromatic compounds * cytokines
    Subject RIV: BO - Biophysics

    The results of the present study indicate that inflammatory conditions might enhance genotoxic effects of carcinogenic polycyclic aromatic hydrocarbons through upregulation of CYP1B1 expression.

    Výsledky této studie naznačují, že zánět může posilovat genotoxické účinky karcinogenních polycyklických aromatických uhlovodíků prostřednictvím zvýšené exprese CYP1B1.
    Permanent Link: http://hdl.handle.net/11104/0169192

     
     
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