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The methylation of monofunctional dienplatin affects conformation of DNA adducts and their processing by DNA polymerases
- 1.0319310 - BFÚ 2009 PL eng A - Abstract
Nováková, Olga - Malina, Jaroslav - Natile, G. - Brabec, Viktor
The methylation of monofunctional dienplatin affects conformation of DNA adducts and their processing by DNA polymerases.
[Metylace monofunkční dienplatiny ovlivňuje konformaci aduktů na DNA a aktivitu DNA polymeráz.]
Abstract Book. Wroclav, 2008. s. 258.
[9th European Biological Inorganic Chemistry Conference. 02.09.2008-06.09.2008, Wroclaw]
R&D Projects: GA ČR(CZ) GA203/06/1239
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : DNA polymerases * DNA adducts * dienplatin
Subject RIV: BO - Biophysics
We investigated DNA polymerization using DNA templates site-specifically modified by the adducts of monofunctional and its methylated derivatives in three sequence contexts. The results indicate that the bulkiness of DNA adducts of monofunctional platinum complexes is a key factor in mechanism of the blockage of DNA polymerases.
Byl studován vliv monofunkčních aduktů dienplatiny a jejích metylovaných derivátů na polymerizační proces u dvou DNA polymeráz. Výsledky ukázaly, že objemnost aduktů je klíčovým faktorem v mechanizmu inhibice vybraných polymeráz.
Permanent Link: http://hdl.handle.net/11104/0168487
Number of the records: 1