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The effect of aldose reductase inhibition by JMC-2004 on hyperglycemia-induced endothelial dysfunction
- 1.0317709 - BFÚ 2009 RIV SE eng J - Journal Article
Papežíková, Ivana - Pekarová, Michaela - Chatzopoulou, M. - Nicolaou, I. - Demopoulos, V. - Kubala, Lukáš - Lojek, Antonín
The effect of aldose reductase inhibition by JMC-2004 on hyperglycemia-induced endothelial dysfunction.
[Vliv inhibice aldosa reduktázy inhibitorem JMC-2004 na endoteliální dysfunkci indukovanou vysokými hladinami glukózy.]
Neuroendocrinology Letters. Roč. 29, č. 5 (2008), s. 775-778. ISSN 0172-780X. E-ISSN 2354-4716.
[13th Interdisciplinary Toxicology Conference TOXCON 2008. Trenčianske Teplice, 27.05.2008-31.05.2008]
R&D Projects: GA ČR(CZ) GP204/07/P539
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : aldose reductase * hyperglycemia * endothelial dysfunction
Subject RIV: BO - Biophysics
Impact factor: 1.359, year: 2008
The effect of aldose reductase inhibition by new inhibitor JMC-2004 was tested on bovine aortic endothelial cells. It was found that aldose reductase inhibition abolishes hyperglycemia-induced endothelial dysfunction.
Na endoteliálních buňkách byl testován vliv inhibice aldosa reduktázy na endoteliální dysfunkci indukovanou vysokými hladinami glukózy. Bylo zjištěno, že inhibice aldosa reduktázy inhibitorem JMC-2004 ruší endoteliální dysfunkci vyvolanou hyperglykémií.
Permanent Link: http://hdl.handle.net/11104/0167291
Number of the records: 1