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On the stereochemistry of C3'-O-P-CH2-O-C4'' phosphonate internucleotide bond, a phosphate isostere
- 1.0312475 - ÚOCHB 2009 RIV GB eng J - Journal Article
Točík, Zdeněk - Buděšínský, Miloš - Barvík Jr., I. - Rosenberg, Ivan
On the stereochemistry of C3'-O-P-CH2-O-C4'' phosphonate internucleotide bond, a phosphate isostere.
[Stereochemie fosfonátové internukleotidové vazby C3'-O-P-CH2-O-C4'', isosterní s vazbou fosfátovou.]
Nucleic Acids Symposium Series. -, č. 52 (2008), s. 427-428. ISSN 0261-3166.
[Joint Symposium of the International Roundtable on Nucleosides, Nucleotides and Nucleic Acids /18./ and the International Symposium on Nucleic Acid Chemistry /35./. Kyoto, 08.09.2008-12.09.2008]
R&D Projects: GA MŠMT(CZ) LC06061
Institutional research plan: CEZ:AV0Z40550506
Keywords : phosphonate oligonucleotide stereochemistry
Subject RIV: CC - Organic Chemistry
Stereochemistry of the isosteric phosphonate linkage was thoroughly studied on model 13C-labeled dimers, using NMR, MDS, and ab initio approaches. Conformational preferences were evaluated.
Byla studována stereochemie internukleotidové vazby isosterní s klasickou vazbou fosfodiesterovou, a to na modelovém značeném thymidylátovém dimeru za užití NMR, MDS a ab-initio metod. Určeny konformační preference.
Permanent Link: http://hdl.handle.net/11104/0163534
Number of the records: 1