Electrochemical analysis of alpha-synuclein protein aggregation in Parkinson's disease

0311401 - BFÚ 2009 CZ eng A - Abstract
Ostatná, Veronika - Masařík, Michal - Bertoncini, C.W. - Jovin, T. - Paleček, Emil
Electrochemical analysis of alpha-synuclein protein aggregation in Parkinson's disease.
[Elektrochemická analýza agregace proteinu alpha-synukleinu v Parkinsonově nemoci.]
Book of Abstracts. Brno, 2008. s. 39.
[Satellite Symposium to ESEAC 2008. Electrochemistry of Nucleic Acids and Proteins. New Tools for Biotechnologies. 19.06.2008-22.06.2008, Brno]
R&D Projects: GA ČR(CZ) GP202/07/P497; GA ČR(CZ) GA301/07/0490; GA MŠMT(CZ) LC06035
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : aggregation * alpha-synuclein * electrochemical analysis
Subject RIV: AQ - Safety, Health Protection, Human - Machine

We have studied the interfacial properties of wild-type AS and the course of its aggregation in vitro using electrochemical analysis, fluorescence and dynamic light scattering. Our recent results suggested that electrochemical methods may be useful in the research of alpha-synuclein aggregation and particularly of formation of the oligomeric intermediates.

Studovali jsme mezifázové vlastnosti AS a také jeho agregaci in vitro (mícháním při 37 st. C) pomocí dynamického rozptylu světla, fluorescence a elektrochemických metod. Naše výsledky demonstrují schopnost využití elektrochemických metod ke studiu alpha-synukleinovou agregaci a zejména formaci oligomerních intermediátů.
Permanent Link: http://hdl.handle.net/11104/0163025