Absence of ethanol-induced interdigitation in supported phospholipid bilayers on silica surfaces

0311025 - ÚFCH JH 2009 RIV US eng J - Journal Article
Miszta, Adam - van Deursen, B. - Schoufs, R. - Hof, Martin - Hermens, W. Th.
Absence of ethanol-induced interdigitation in supported phospholipid bilayers on silica surfaces.
[Absence etanol-indukované interdigitace na nosiči fosfolipidových dvouvrstev na křemičitých plochách.]
Langmuir. Roč. 24, č. 1 (2008), s. 19-21. ISSN 0743-7463
R&D Projects: GA MŠMT(CZ) LC06063; GA ČR GA203/05/2308
Institutional research plan: CEZ:AV0Z40400503
Keywords : lipid vesicle adsorption * unilamelar vesicles * planar bilayers
Subject RIV: CF - Physical ; Theoretical Chemistry
Impact factor: 4.097, year: 2008

Membranes prepared by the adsorption of phospholipid vesicles on solid supports are much-used model systems in biomedical research. However, there is accumulating evidence that such membranes may not always be equivalent to the free-standing cellular membranes that they are modeling. In the present study, sonicated DOPC/DOPS (80/20 mol %) vesicles were adsorbed on hydrophilic silica surfaces, a system that has been demonstrated to produce confluent bilayers. In addition, pure DOPC and DLPC membranes were studied. It is demonstrated that ethanol-induced membrane interdigitation, as demonstrated for free-standing bilayers, does not occur in these supported membranes.

Absence etanol-indukované interdigitace na nosiči fosfolipidových dvouvrstev na křemičitých plochách.
Permanent Link: http://hdl.handle.net/11104/0004717