Synthesis of 8-C-substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-couplin

0310044 - ÚOCHB 2009 RIV CZ eng C - Conference Paper (international conference)
Sedláček, Ondřej - Pohl, Radek - Holý, Antonín
Synthesis of 8-C-substituted 2,6-diaminopurine acyclic nucleoside phosphonates by Negishi cross-couplin.
[Příprava 8-C-substituovaných acyklických nukleosidfosfonátů odvozených od 2,6 diaminopurinu s využitím Negishiho cross-couplingu.]
Chemistry of Nucleic Acid Components. Praha: Institute of Organic Chemistry and Biochemistry ASCR, 2008 - (Hocek, M.), s. 449-450. Collection Symposium Series, 10. ISBN 978-80-86241-29-6.
[Symposium on Chemistry of Nucleic Acid Components /14./. Český Krumlov (CZ), 08.06.2008-13.06.2008]
R&D Projects: GA MŠMT 1M0508; GA AV ČR 1QS400550501
Grant - others:NIH(US) 1UC1A1062540-01
Institutional research plan: CEZ:AV0Z40550506
Keywords : 8-C-substituted * Negishi cross-coupling * acyclic nucleoside phosphonates * 2,6-diaminopurine
Subject RIV: CC - Organic Chemistry

8-Allyl-, cyclopropyl-, trifluoromethyl-, cyano-, carbethoxy- and acetaldehydo-2,6-diamino- 9-[2-(phosphonomethoxy)ethyl]purine (PMEDAP) were prepared by Negishi cross-coupling of the 8-bromo-PMEDAP under catalysis with Pd2dba3 with various phosphine ligands followed by deprotection.

8-Allyl-, cyklopropyl-, trifluoromethyl-, kyano-, karbethoxy- and acetaldehydo-2,6-diamino- 9-[2-(fosfonomethoxy)ethyl]purin (PMEDAP) byly připraveny pomocí Negishiho cross-couplingu z 8-brom-PMEDAPu za katalýzy Pd2dba3 s různými fosfinovými ligandy a jeho následnou deprotekcí.
Permanent Link: http://hdl.handle.net/11104/0162026