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Effect of carvedilol on the production of reactive oxygen species by HL-60 cells
- 1.0309265 - BFÚ 2009 SK eng A - Abstract
Lojek, Antonín - Pečivová, J. - Mačičková, T. - Nosál, R. - Papežíková, Ivana - Číž, Milan
Effect of carvedilol on the production of reactive oxygen species by HL-60 cells.
[Vliv carvedilolu na produkci reaktivních kyslíkových metabolitů buňkami linie HL-60.]
Programme & Abstracts. Trenčianske Teplice, 2008. s. 92. ISSN 1337-6853.
[TOXCON 2008, Integration of Toxicological Research Within V4, 13th Interdisciplinary Toxicology Conference. 27.05.2008-30.05.2008, Trenčianske Teplice]
R&D Projects: GA AV ČR(CZ) 1QS500040507; GA ČR(CZ) GA524/08/1753
Institutional research plan: CEZ:AV0Z50040507; CEZ:AV0Z50040702
Keywords : carvedilol * reactive oxygen species * HL-60
Subject RIV: BO - Biophysics
We observed that carvedilol in concentrations higher than 1 uM: i) potentiates the oxidative burst of HL-60 cells, ii) carvedilol has very powerful antioxidative properties and iii) carvedilol dose dependently inhibits MPO activity.
Bylo zjištěno, že carvedilol v koncentraci větší než 1 uM: i) potencuje oxidativní vzplanutí buněk HL-60, ii) vykazuje silné antioxidační účinky a iii) inhibuje aktivitu myeloperoxidasy.
Permanent Link: http://hdl.handle.net/11104/0161453
Number of the records: 1