Influence of intestinal bacteria on colitis developing in SCID mice reconstituted with CD4+CD45RBhigh T cells on the changes of tight junctions (TJs) and Paneth cells

0306939 - MBÚ 2008 RIV SIGLE AT eng C - Conference Paper (international conference)
Štěpánková, Renata - Powrie, F. - Kofroňová, Olga - Kozáková, Hana - Hudcovic, Tomáš - Hrnčíř, Tomáš - Tlaskalová, Helena
Influence of intestinal bacteria on colitis developing in SCID mice reconstituted with CD4+CD45RBhigh T cells on the changes of tight junctions (TJs) and Paneth cells.
[Vliv střevních bakterií na vývoj kolitidy u SCID myší po přenosu T buněk CD4+CD45RBhigh na změny TJs a yměny v Panetových buňkách.]
Congress of the European Crohn´s and Colitis Organisation. Innsbruck: Springer, 2007, s. 44-44.
[Congress of the European Crohn´s and Colitis Organisation. Innsbruck (AT), 01.03.2007-03.03.2007]
R&D Projects: GA ČR GA303/04/0849
Grant - others:XE(XE) EU QLGI-199-00050
Institutional research plan: CEZ:AV0Z50200510
Source of funding: R - Framework programmes of European Commission
Keywords : colitis
Subject RIV: EC - Immunology

We found in inflammated colon decreased production of mucus by goblet cells as an important feature of intestinal inflammation. Simultaneously in inflammated tissue impairment of tight junctions (TJs) detected by changes in ZO-1 and Claudin-1 expression was found in terminal ileum. We did not detect α- defensin (Cryptdin- 4) expression on inflammed ileal mucosa

My jsme nalezli v zánětlivé tkáni kolonu sníženou produkci mukusu a nižší počet pohárkových buněk. V terminálním ileu v zánětlivé tkáni pak byly detekovány změny Tight junctions (TJs) as ZO-1 a Claudin-1 a snížená exprese α-defensinu (Cryptdinu-4) v Panetových buňkách
Permanent Link: http://hdl.handle.net/11104/0159831