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The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells
- 1.0213610 - UZFG-Y 20033079 RIV US eng J - Journal Article
Anger, Martin - Bryja, Vítězslav - Jirmanová, L. - Hampl, Aleš - Carrington, M. - Motlík, Jan - Dvořák, Petr - Kubelka, Michal
The appearance of truncated cyclin A2 correlates with differentiation of mouse embryonic stem cells.
Biochemical and Biophysical Research Communications. Roč. 302, - (2003), s. 825-830. ISSN 0006-291X. E-ISSN 1090-2104
R&D Projects: GA ČR GA523/00/0780; GA MŠMT LN00A065
Institutional research plan: CEZ:AV0Z5045916; CEZ:AV0Z5039906; CEZ:MSM 432100001
Keywords : mouse embryonic stem cell
Subject RIV: ED - Physiology
Impact factor: 2.836, year: 2003
The presence of truncated form of cyclin A2 has been reported in various murine cell lines and tissues. In this paper it was shown that while undifferentiated proliferating mouse embryonic stem cells express low levels of this truncated cyclin A2, cells that are induced to differentiate remarkably increase its synthesis. Importantly, the expression pattern of truncated cyclin A2 was the same in p27 -/- ES cells as in the wild-type ES cells. Thus, it suggests that p27 is not necessary for the proteolytic cleavage of cyclin A2 and that this post-translational modification correlates with differentiation.
Permanent Link: http://hdl.handle.net/11104/0109145
Number of the records: 1