Chromosome Condensation in Pig Oocytes: Lack of a requirement for Either cdc2 Kinase or MAP Kinase Activity

0213511 - UZFG-Y 20023127 RIV US eng J - Journal Article
Kubelka, Michal - Anger, Martin - Kalous, Jaroslav - Schultz, R. M. - Motlík, Jan
Chromosome Condensation in Pig Oocytes: Lack of a requirement for Either cdc2 Kinase or MAP Kinase Activity.
Molecular Reproduction and Development. Roč. 63, - (2002), s. 110-118. ISSN 1040-452X. E-ISSN 1098-2795
R&D Projects: GA ČR GA203/99/1459; GA AV ČR KSK5052113
Grant - others:GA XE(XE) QLRT-1999-00104
Keywords : GVBD * chromosome condensation * okadaic acid
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.322, year: 2002

In this study, butyrolactone I (BL I), a potent and specific inhibitor of cyclin-dependent kinases (cdk), is shown to inhibit germinal vesicle breakdown (GVBD) in pig oocytes. Results suggest that both chromosome condensation and GVBD could occur without activation of cdc2 kinase, whereas an increase in MAP kinase activity may be a requisite for GVBD in pig oocytes in conditions when cdc2 kinase activation is blocked by BL I.
Permanent Link: http://hdl.handle.net/11104/0109047