Pig model in the study on apoptotic DNA fragmentation during cardiopulmonary bypass

0213489 - UZFG-Y 20023105 RIV LV eng J - Journal Article
Matalová, Eva - Španová, A. - Kovářů, F.
Pig model in the study on apoptotic DNA fragmentation during cardiopulmonary bypass.
Baltic Journal of Laboratory Animal Science. Roč. 12, - (2002), s. 154-158. ISSN 1407-0944
R&D Projects: GA ČR GA304/01/0850; GA AV ČR KSK6005114
Keywords : pig model * apoptosis * cardiopulmonary bypass
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery

Pigs reperesent an important experimental model in studies of morphological, immunological and other biomedical mechanisms. This work examined activation of apoptosis under experimental conditions of cardiopulmonary bypass (CPB). The aim of this study was to observe the influence of CPB on apoptotic DNA changes in the most exposed tissues, mainly heart, lung, blood and bone marrow cells. Our results suggest that programmed cell death can play an important role in pathophysiological consequences of CPB.
Permanent Link: http://hdl.handle.net/11104/0109025