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FGF-2 abnormalities in B cell chronic lymphotic and chronic myeloid leukemias
- 1.0213271 - UZFG-Y 20010009 RIV GB eng J - Journal Article
Krejčí, P. - Dvořáková, D. - Krahulcová, E. - Pacherník, J. - Mayer, J. - Hampl, Aleš - Dvořák, Petr
FGF-2 abnormalities in B cell chronic lymphotic and chronic myeloid leukemias.
Leukemia. Roč. 15, - (2001), s. 228-237. ISSN 0887-6924. E-ISSN 1476-5551
R&D Projects: GA ČR GA312/97/0393; GA MŠMT VS96115
Keywords : leukemia * FGF-2
Subject RIV: FD - Oncology ; Hematology
Impact factor: 4.293, year: 2001
FGF-2 abnormalities in B cell chronic lymphotic and chronic myeloid leukemias.We conclude that B-CLL WBCs secrete FGF-2 with no apparent autocrine actions. In contrast, WBCs in CML bind FGF-2 provided by other FGF-2-hyperproducing cells and activate the MEK/ERK kinase cascade, possibly to modulate cell growth.
Permanent Link: http://hdl.handle.net/11104/0108809
Number of the records: 1