Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II

0212402 - UT-L 20030119 RIV CZ eng C - Conference Paper (international conference)
Pásek, Michal - Christé, G. - Šimurda, J.
Quantitative modelling of effect of transverse - axial tubular system on electrical activity of cardiac cells: Development of model II.
Engineering mechanics 2003. Praha: UTAM AV ČR, 2003 - (Náprstek, J.; Fischer, C.), s. 1-9. ISBN 80-86246-18-3.
[Engineering Mechanics 2003. Svratka (CZ), 12.05.2003-15.05.2003]
R&D Projects: GA ČR GP204/02/D129
Institutional research plan: CEZ:AV0Z2076919
Keywords : cardiac cell * tubular system * quantitative modelling
Subject RIV: BO - Biophysics

In this work, we present a new version of cardiac ventricular cell model incorporating the transverse - axial tubular system. The improvements include reformulated description of L-type Ca2+ channel, of Ca2+ induced Ca2+ release from sarcoplasmic reticulum, of intracellular Ca2+ buffering and incorporation of potassium currents Ito, IK(Na) and IK(ATP). In comparison with the previous model (Pásek et al., 2002), the steady state simulations revealed more profound changes of tubular ionic concentration (12.8 % for Ca2+ and 4.7 % for K+ at 1 Hz). The refined model will be used for more exact quantitative exploration of the effect of transverse - axial tubular system on cellular electrical activity and excitation - contraction coupling.
Permanent Link: http://hdl.handle.net/11104/0107950