"Baseline" Problems in Very Short Echo-time Proton MR Spectroscopy of Low Molecular Weight Metabolites in the Brain

0205374 - UPT-D 20010013 RIV SK eng C - Conference Paper (international conference)
Starčuk, Zenon - Starčuk jr., Zenon - Horký, Jaroslav
"Baseline" Problems in Very Short Echo-time Proton MR Spectroscopy of Low Molecular Weight Metabolites in the Brain.
Proceedings of the 3nd International Conference on Measurement - Measurement 2001. Bratislava: Institute of Measurement Science, Slovak Academy of Sciences, 2001 - (Frollo, I.; Plačková, A.), s. 89-92. ISBN 80-967402-5-3.
[Measurement 2001 /3./. Smolenice (SK), 14.05.2001-17.05.2001]
R&D Projects: GA AV ČR IAA4065901
Institutional research plan: CEZ:AV0Z2065902
Keywords : short echo-time proton MR spectra * metabolite signals
Subject RIV: JA - Electronics ; Optoelectronics, Electrical Engineering

Accurate and reliable quantification of low molecular weight metabolites in short echo-time proton MR spectra of the brain is usually considerably complicated by an uncharacterized broad baseline extending over the whole frequency range of the metabolite signals of interest. Several sequences providing pure MR spectra of cerebral metabolites were designed, computer analyzed and experimentally tested. In these sequences, precautions have been made to avoid baseline contributions due to experimental imperfections, and signals of low molecular weight metabolites were distinguished from those of macromolecules (lipids), which are substantial contributors to the broad baseline, by utilizing the differences between their T₁relaxation times.
Permanent Link: http://hdl.handle.net/11104/0100988