0194917 - UOCHB-X 20030225 RIV US eng J - Journal Article
Králíková, Šárka - Buděšínský, Miloš - Rosenberg, Ivan
ŕ-Hydroxyphosphonate oligonucleotides: A promising DNA type?
Nucleosides Nucleotides & Nucleic Acids. Roč. 22, 5/8 (2003), s. 1061-1064. ISSN 1525-7770. E-ISSN 1532-2335.
[International Roundtable Nucleosides, Nucleotides and Nucleic Acids /15./. Leuven, 10.09.2002-14.09.2002]
R&D Projects: GA ČR GA203/01/1166; GA AV ČR IAA4055101
Institutional research plan: CEZ:AV0Z4055905
Keywords : isopolar phosphonate oligonucleotides * nucleoside 5'-phosphonic acids * phosphotriester method
Subject RIV: CC - Organic Chemistry
Impact factor: 0.813, year: 2003

The synthesis of monomers (.I.S./I.)-1, (.I.R./I.)-1 and 2 derived from (5'.I.S./I.)-, (5'.I.R./I.)-2'-deoxy-thymidine-5'-.I.C./I.-phosphonic acids and 2',5'-dideoxythymidine-5'-.I.C./I.-phosphonic acid was elaborated. The protection of the 5'-hydroxyl by the methoxycarbonyl group was a key step of the synthesis.
Permanent Link: http://hdl.handle.net/11104/0090587