Magnesium and biological activity of oxytocin analogues modified on aromatic ring of amino acid in position 2

0194324 - UOCHB-X 20010169 RIV GB eng J - Journal Article
Slaninová, Jiřina - Maletínská, Lenka - Vondrášek, Jiří - Procházka, Zdenko
Magnesium and biological activity of oxytocin analogues modified on aromatic ring of amino acid in position 2.
Journal of Peptide Science. Roč. 7, - (2001), s. 413-424. ISSN 1075-2617. E-ISSN 1099-1387
R&D Projects: GA ČR GA204/99/1453; GA MŠMT LN00A032; GA AV ČR IAA4055602
Institutional research plan: CEZ:AV0Z4055905
Keywords : magnesium * oxytocin analogues
Subject RIV: CE - Biochemistry
Impact factor: 1.451, year: 2001

6 OT analogues ([D- and L-.I.m./I.-Me-Phe²]OT, [D-and L-.I.m./I.-OMe-Phe²]OT and [D- and L-.I.o./I.-Me-Tyr²]OT) were synthesized and several previously described analogues resynthesized. Is was found that in the absence of Mg2+ substitution of the .I.o./I.- and .I.m./I.-position leads to loss of intrinsic activity in contrast to the .I.p./I.-position.
Permanent Link: http://hdl.handle.net/11104/0090002