0193831 - UOCHB-X 20000293 RIV US eng J - Journal Article
Krejčová, Romana - Horská, Květoslava - Votruba, Ivan - Holý, Antonín
Interaction of Guanine Phosphonomethoxyalkyl Derivatives with GMP Kinase Isoenzymes.
Biochemical Pharmacology. Roč. 60, - (2000), s. 1907-1913. ISSN 0006-2952. E-ISSN 1873-2968
R&D Projects: GA ČR GV203/96/K001; GA MZd NL5423
Institutional research plan: CEZ:AV0Z4055905
Subject RIV: CE - Biochemistry
Impact factor: 2.975, year: 2000

Substrate activity and inhibitory potency of guanine and structurally related 2,6-diaminopurine phosphonomethoxyalkyl derivatives towards GMP kinase isoenzymes from L1210 cells was studied. Kinetic data have shown that (R)-PMPG was a good substrate. The inhibitory activities of the individual compounds on GMP kinase isoenzymes decreased in the following order: (S)-HPMPG>(R)-PMPG>PMEG>(R)-HPMPG>(S)-PMPG>PMEDAP=(R)-PMPDAP=(S)-PMPDAP.
Permanent Link: http://hdl.handle.net/11104/0089523