Desoctapeptideinsulin: Substrate of ŕ-chymotrypsin

0193690 - UOCHB-X 20000040 RIV SIGLE CZ eng C - Conference Paper (international conference)
Koubová, V. - Barthová, J. - Barth, Tomislav - Bezouška, K. - Ubik, Karel - Kašička, Václav
Desoctapeptideinsulin: Substrate of ŕ-chymotrypsin.
80-86241-06-8. In: Biologically Active Peptides. Praha: ÚOCHB AVČR, 1999 - (Slaninová, J.; Barth, T.), s. 91-93. Collection Symposium Series., 3.
[Biologically Active Peptides. Conference /6./. Praha (CZ), 21.04.1999-23.04.1999]
R&D Projects: GA MPO PZ-Z2/32
Institutional research plan: CEZ:AV0Z4055905
Keywords : ŕ-chymotrypsin
Subject RIV: CE - Biochemistry

Desoctapeptideinsulin (DOI) contains three tyrosine residues and therefore it represents a suitable substrate for ŕ-chymotrypsin. The detailed enzymic study reveated a series of intermediates and final products. The bonds formed by tyrosine A14 and B16 are attacked as the first, and the products are further desintagrated.
Permanent Link: http://hdl.handle.net/11104/0089385