Desoctapeptideinsulin fragments formed by chymotryptic cleavage and suitable for modification of insulin in positions A 14 and B 16

0193689 - UOCHB-X 20000039 RIV SIGLE CZ eng C - Conference Paper (international conference)
Koubová, V. - Barthová, J. - Kašička, Václav - Ubik, Karel - Barth, Tomislav - Bezouška, K.
Desoctapeptideinsulin fragments formed by chymotryptic cleavage and suitable for modification of insulin in positions A 14 and B 16.
80-86241-06-8. In: Biologically Active Peptides. Praha: ÚOCHB AVČR, 1999 - (Slaninová, J.; Barth, T.), s. 88-90. Collection Symposium Series., 3.
[Biologically Active Peptides. Conference /6./. Praha (CZ), 21.04.1999-23.04.1999]
R&D Projects: GA MPO PZ-Z2/32
Institutional research plan: CEZ:AV0Z4055905
Keywords : DOI-Fragments
Subject RIV: CE - Biochemistry

The molecule of desoctapeptide insulin is cleaved by ŕ-chymotrypsin at the three tyrosine residues. The fragments with tyrosine C-terminal residues are candidates of semisynthetic modification. They were isolated and characterized by HPLC, capillary electrophoresis and mass spectrometry.
Permanent Link: http://hdl.handle.net/11104/0089384