The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors

0191637 - UMG-J 20033145 RIV US cze J - Journal Article
Karafiát, Vít - Dvořáková, Marta - Pajer, Petr - Králová, Jarmila - Hořejší, Václav - Čermák, Vladimír - Bartůněk, Petr - Zenke, M. - Dvořák, Michal
The leucine zipper region of Myb oncoprotein regulates the commitment of hematopoietic progenitors.
Blood. Roč. 2001, č. 98 (2001), s. 3668-3676. ISSN 0006-4971. E-ISSN 1528-0020
R&D Projects: GA AV ČR IPP2052002
Institutional research plan: CEZ:AV0Z5052915
Keywords : BLOOD-CELL DIFFERENTIATION * TRANSCRIPTION FACTOR * V-MYB
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 9.273, year: 2001

The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature elements belonging to at least 8 different lineages. The lineage choice process during which stem cells and progenitors commit to a particular lineage is regulated by a coordinated action of extracellular signals and transcription factors. Molecular mechanisms controlling commitment are largely unknown. Here, the transcription factor v-Myb and its leucine zipper region (LZR) are identified as regulators of the commit ment of a common myeloid progenitor and progenitors restricted to the myeloid lineage.
Permanent Link: http://hdl.handle.net/11104/0087375