Genomic organization of the mouse src gene. Sequencing of src introns revealed a new chromosome 2 microsatellite marker

0191636 - UMG-J 20033144 RIV CZ eng J - Journal Article
Fučík, Vladimír - Beran, Jaroslav - Černý, Zbyněk - Mácha, J. - Jonák, Jiří
Genomic organization of the mouse src gene. Sequencing of src introns revealed a new chromosome 2 microsatellite marker.
Folia Biologica. Roč. 2002, č. 48 (2002), s. 34-39. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA AV ČR IPP2052002
Institutional research plan: CEZ:AV0Z5052915
Keywords : Mus musculus * protein tyrosine kinase * c-src
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.615, year: 2002

Ten introns interrupting the coding sequence of the mouse src protooncogene were sequenced (in total 11260 bp) and their general characteristics compared with the homologous genes in human and chicken. While the study of genome organization of the src gene was performed only in the inbred mouse strain BALB/cHeA (Mus musculus domesticus), one special region in the intron 5 was also sequenced in additional mouse strains (M. musculus musculus and M. spretus), because the discovered CA and GT repeat array differences could serve as a new polymorphic marker in the chromosome No. 2 and help elucidate some evolutionary relations between mouse strains.
Permanent Link: http://hdl.handle.net/11104/0087374