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The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors
- 1.0191374 - UMG-J 20010445 RIV US eng J - Journal Article
Karafiát, Vít - Dvořáková, Marta - Pajer, Petr - Králová, Jarmila - Hořejší, Z. - Čermák, Vladimír - Bartůněk, Petr - Zenke, M. - Dvořák, Michal
The leucine zipper region of Myb oncoprotein regulates commitment of hematopoietic progenitors.
Blood. Roč. 98, - (2001), s. 3668-3676. ISSN 0006-4971. E-ISSN 1528-0020
R&D Projects: GA ČR GV301/98/K042; GA AV ČR IAA5052805
Grant - others:HHMI(US) 75195-540401
Institutional research plan: CEZ:AV0Z5052915
Keywords : hamatopoiesis * commitment * Myb
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 9.273, year: 2001
The development of blood cells proceeds from pluripotent stem cells through multipotent progenitors into mature cells belonging to at least eight different leneages. We found that the leucine zipper region (LZR) of the v-Myb transcription factor affets the lineage commitment of myeloid progenitors. We propose that Myb LZR can function as a molecular switch affecting expression of lineage specifying factors and directing the development of hematopoietic progenitors into either myeloid or erythroid lineages.
Permanent Link: http://hdl.handle.net/11104/0087127
Number of the records: 1