J3-crystallin of the jellyfish lens: similarity to saposins

0191342 - UMG-J 20010412 RIV US eng J - Journal Article
Piatigorsky, J. - Norman, B. - Dishaw, L. J. - Kos, L. - Horwitz, J. - Steinbach, P. J. - Kozmik, Zbyněk
J3-crystallin of the jellyfish lens: similarity to saposins.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 98, č. 22 (2001), s. 12362-12367. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA MŠMT LN00A079
Keywords : crystallin * jellyfish * lens
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 10.890, year: 2001

J3-crystallin, one of the three major eye-lens proteins of the cubomedusan jellyfish (Tripedalia cystophora), shows similarity to vertebrate saposins, which are multifunctional proteins that bridge lysosomal hydrolases to lipids and activate enzyme activity. Our data suggest a crystallin role for the multifunctional saposin protein family in the jellyfish lens. This finding extends the gene sharing evolutionary strategy for lens crystallins to the cnidarians.
Permanent Link: http://hdl.handle.net/11104/0087095