Differing sensitivity of tumor cells to apoptosis induced by iron deprivation in vitro

0191279 - UMG-J 20010349 RIV US eng J - Journal Article
Kovář, Jan - Valenta, Tomáš - Štýbrová, H.
Differing sensitivity of tumor cells to apoptosis induced by iron deprivation in vitro.
In Vitro - Cellular and Developmental Biology. Animal Section. Roč. 37, č. 7 (2001), s. 450-458. ISSN 1071-2690. E-ISSN 1543-706X
R&D Projects: GA ČR GA301/97/1029
Keywords : sensitivity to apoptosis * apoptosis induction * iron deprivation
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.263, year: 2001

We studied the sensitivity of tumor cells to the induction of apoptosis by iron deprivation. Iron deprivation was achieved by the employment of a defined iron-deficient culture medium. We conclude that some tumor cells in vitro are sensitive to apoptosis induction by iron deprivation, while other tumor cells are resistant. All the tumors found to be sensitive to iron deprivation in this study (four cell lines) are of hematopoietic origin. The mechanism of resistance to apoptosis induction by iron deprivation differs from the mechanism of resistance to thiol deprivation.
Permanent Link: http://hdl.handle.net/11104/0087034