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Genetically modified dendritic cell-based cancer vaccines
- 1.0191269 - UMG-J 20010339 RIV CZ eng J - Journal Article
Bubeník, Jan
Genetically modified dendritic cell-based cancer vaccines.
Folia Biologica. Roč. 47, č. 5 (2001), s. 153-155. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA MZd NC5526
Keywords : dendritic cells * cancer vaccines
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.519, year: 2001
The capacity to present antigens, activate naive T cells and induce primary cellular immunity make DC attractive vehicles for delivery of therapeutic cancer vaccines. Genetically modified DC vaccines can be prepared by transfection with polynucleotides coding for oncoproteins, immunostimulatory cytokines and/or co-stimulatory molecules, transduction with recombinant viral vectors encoding these molecules and tumour cell-DC fusion. The therapeutic effects of these vaccines .I.in ./I. .I.vitro ./I.and .I.in vivo ./I.are discussed.
Permanent Link: http://hdl.handle.net/11104/0087024
Number of the records: 1