Additive stimulatory effect of extracellular calcium and potassium on non-transferrin ferric iron uptake by HeLa and K562 cells

0191243 - UMG-J 20010313 RIV NL eng J - Journal Article
Musílková, Jana - Kovář, Jan
Additive stimulatory effect of extracellular calcium and potassium on non-transferrin ferric iron uptake by HeLa and K562 cells.
Biochimica et biophysica acta. Roč. 1514, č. 1 (2001), s. 117-126. ISSN 0006-3002
R&D Projects: GA AV ČR IAA5052702
Institutional research plan: CEZ:AV0Z5052915
Keywords : non-transferrin iron * iron uptake * K562 cells
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.590, year: 1999

We studied the effects of Ca 2+ and K + on non-transferrin iron uptake from ferric citrate complex by HeLa and K562 cells. We conclude that extracellular calcium per se, and not intracellular calcium or Ca 2+ transport, stimulates ferric iron uptake. A high level of extracellular K + also stimulates the uptake, probably via cell membrane depolarization. Na + is not involved in these stimulations of iron uptake. The transient K + effect and continuous Ca 2+ effect seem to be additive.
Permanent Link: http://hdl.handle.net/11104/0086998