The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing

0191237 - UMG-J 20010308 RIV US eng J - Journal Article
Homeister, J. W. - Thall, A. D. - Petryniak, B. - Malý, Petr - Rogers, C. E. - Smith, P. L. - Kelly, R. J. - Gersten, K. M. - Askari, S. W. - Cheng, G.
The alpha(1,3)fucosyltransferases FucT-IV and FucT-VII exert collaborative control over selectin-dependent leukocyte recruitment and lymphocyte homing.
Immunity. Roč. 15, č. 1 (2001), s. 115-126. ISSN 1074-7613. E-ISSN 1097-4180
Institutional research plan: CEZ:AV0Z5052915
Keywords : fucosyltransferase * selectin ligand * gene knock-out
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 18.866, year: 2001

Inflammation-dependent leukocyte recruitment retained in FucT-VII deficiency is extinguished in FucT-IV(-/-)/FucT-VII (-/-) mice. Double deficiency yields an extreme leukocytosis and contributes to HEV-born L-selectin ligands,since lymphocyte homing retained in FucT-VII(-/) mice is revoked in FucT-IV(-/)/FucT-VII(-/-) mice. These observations reveal essential FucT-IV-dependent contributions to E-, P-, and L-selectin ligand synthesis and to the control of leukocyte recruitment and lymphocyte homing.
Permanent Link: http://hdl.handle.net/11104/0086993