Transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain

0191222 - UMG-J 20010293 RIV US eng J - Journal Article
Kirchgesser, H. - Dietrich, J. - Scherer, J. - Isomaki, P. - Kořínek, Vladimír - Hilgert, Ivan - Bruyns, E. - Leo, A. - Cope, A. P. - Schraven, B.
Transmembrane adaptor protein TRIM regulates T cell receptor (TCR) expression and TCR-mediated signaling via an association with the TCR zeta chain.
Journal of Experimental Medicine. Roč. 193, č. 11 (2001), s. 1269-1283. ISSN 0022-1007. E-ISSN 1540-9538
R&D Projects: GA ČR GA204/99/0367
Institutional research plan: CEZ:AV0Z5052915
Keywords : receptor * adaptor protein * signaling
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 15.340, year: 2001

Adaptor protein TRIM preferentially interacts with the TCRvia the TCR-y and CD3-eg. Overexpression of TRIM cells results in enhancement of TCR expression and elevated induction of Ca(2+) mobilization. TRIM-mediated upregulation of TCR expression results from inhibition of spontaneous TCR internalization of TCR complexes on the cell surface. TRIM is a novel component of the TCR complex modulating the strength of TCR signals through regulation of TCR expression on the cell surface.
Permanent Link: http://hdl.handle.net/11104/0086979