An .I.ex vivo ./I.model to study v-Myb-induced leukemogenicity

0191180 - UMG-J 20010249 RIV CA eng J - Journal Article
Dvořáková, Marta - Králová, Jarmila - Karafiát, Vít - Bartůněk, Petr - Dvořák, Michal
An .I.ex vivo ./I.model to study v-Myb-induced leukemogenicity.
Blood Cells Molecules and Diseases. Roč. 27, č. 2 (2001), s. 437-445. ISSN 1079-9796. E-ISSN 1096-0961
R&D Projects: GA ČR GV301/98/K042; GA ČR GA204/00/0554; GA AV ČR IPP2052002
Grant - others:HHMI(US) 75195-540401
Institutional research plan: CEZ:AV0Z5052915
Keywords : v-Myb oncoprotein * PEST domain * leucine zipper
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 1.703, year: 2001

The v-Myb oncoprotein transforms myeloid cells and induces acute monoblastic leukemia in chickens. We found that deletion of v-Myb PEST-like (P1) domain almost eliminates presence of leukemic monoblasts in the peripheral blood but not their accumulation in the bone marrow (BM). Ex vivo experiments used to compare wild type (wt) and ëP1 v-Myb BM monoblasts led to the conclusion that leukemia formation requires the growth factor independency and specific adhesion properties induced in monoblasts by wt v-Myb.
Permanent Link: http://hdl.handle.net/11104/0086937