Induction of specific transplantation immunity by oral immunization with allongenic cells

0191091 - UMG-J 20000194 RIV GB eng J - Journal Article
Holáň, Vladimír - Zajícová, Alena - Krulová, Magdalena - Plšková, Jarmila - Frič, Jan - Filipec, M.
Induction of specific transplantation immunity by oral immunization with allongenic cells.
Immunology. Roč. 101, - (2000), s. 404-411. ISSN 0019-2805. E-ISSN 1365-2567
R&D Projects: GA ČR GA310/99/0360; GA ČR GA310/97/1261; GA ČR GA310/99/D044; GA MZd IZ3964; GA MŠMT VS97099
Institutional research plan: CEZ:AV0Z5052915
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 2.292, year: 2000

The intensity of lymphocyte reaction depends on the genetic differences between donors of the responding andstimulating cells. In mice, the strongest response is induced by the differences in the major histocompatibility complex (MHC) and Mls1 antigen. However, even with comparable differences in these antigens, some mousestrains respond better than other, which means that the intensity of this reaction can be influenced by other factors. Using the binding analysis of F2 hybrids between the strains ocB-9 and O20 carrying identical MHC antigens, we have identified a new locus Alan 2 (Alloantigen response 2) on chromosome 4, which controls the response to alloantigens C57L/10, BALB/c, and CBA.
Permanent Link: http://hdl.handle.net/11104/0086848