PWD/Ph and PWK/Ph inbred mouse strains of Mus .I.m. musculus ./I.Subspecies - a Valuable Resource of Phenotypic Variations and Genomic Polymorphisms

0190908 - UMG-J 20000250 RIV CZ eng J - Journal Article
Gregorová, Soňa - Forejt, Jiří
PWD/Ph and PWK/Ph inbred mouse strains of Mus .I.m. musculus ./I.Subspecies - a Valuable Resource of Phenotypic Variations and Genomic Polymorphisms.
Folia Biologica. Roč. 46, č. 1 (2000), s. 31-42. ISSN 0015-5500. E-ISSN 0015-5500
R&D Projects: GA ČR GV204/98/K015; GA ČR GA301/99/0354; GA AV ČR IAA5052709; GA AV ČR KSK2052601; GA AV ČR IPP2020702
Institutional research plan: CEZ:AV0Z5052915
Subject RIV: EB - Genetics ; Molecular Biology
Impact factor: 0.351, year: 2000

PWD/Ph and PWK/Ph are highly inbred mouse strains derived from wild mice of .I.Mus. m. musculus ./I.subspecies. Since classical laboratory mice are mostly of .I.Mus. m. domesticus ./I.origin they display plethora of differences in many complex phenotypes such as blood levels of intermediate metabolites, sensitivity to type-1 diabetes or behaviour when compared with PWK/Ph and PWD/Ph strains. These complex traits can be genetically dissected by QTL analysis using microsatellite markers of known genetic location. Thus the PWD/Ph and PWK/Ph strains are a valuable resource in functional genomics projects.
Permanent Link: http://hdl.handle.net/11104/0086671