Number of the records: 1
Antibody-targeted polymer conjugates of drugs
- 1.0188309 - UMCH-V 20010082 RIV US eng C - Conference Paper (international conference)
Ulbrich, Karel - Etrych, Tomáš - Chytil, Petr - Jelínková, Markéta - Říhová, Blanka
Antibody-targeted polymer conjugates of drugs.
Proceedings. San Diego: Controlled Release Society, 2001, s. No.0226.
[International Symposium on Controlled Release of Bioactive Materials. San Diego (US), 23.06.2001-27.06.2001]
R&D Projects: GA ČR GV307/96/K226; GA AV ČR KSK4055109
Institutional research plan: CEZ:AV0Z4050913
Subject RIV: ED - Physiology
The paper describes synthesis, in vitro drug release, and in vivo biological activity of antibody-targeted drugs based on HPMA copolymers. In the conjugates, cytotoxic drug doxorubicin is attached to the polymer via hydrolytically or enzymatically degradable spacers. The conjugates are being developed as potential anticancer drugs facilitating site-specific therapy.
Permanent Link: http://hdl.handle.net/11104/0084272
Number of the records: 1