Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy

0188308 - UMCH-V 20010081 RIV US eng C - Conference Paper (international conference)
Souček, J. - Strohalm, Jiří - Plocová, Daniela - Poučková, P. - Hloušková, D. - Zadinová, M. - Ulbrich, Karel
Polymer conjugates of bovine pancreatic ribonuclease (RNase A) for cancer therapy.
Proceedings. San Diego: Controlled Release Society, 2001, s. No.6132.
[International Symposium on Controlled Release of Bioactive Materials. San Diego (US), 23.06.2001-27.06.2001]
R&D Projects: GA ČR GV307/96/K226; GA AV ČR KSK4055109
Institutional research plan: CEZ:AV0Z4050913
Keywords : RNase A * polymer conjugates * drug delivery
Subject RIV: ED - Physiology

RNase A unimer was conjugated with two N-(2-hydroxypropyl)methacrylamide (HPMA) copolymers, forming classic and starconjugates. Their antitumor effects were tested both in vitro and in vivo. Unlike the wild bovine pancreatic ribonuclease (RNase A), both polymer conjugates injected intraperitoneally or intravenously displayed a potent antitumor activity in nude mice bearing human melanoma. At the same time, their cytotoxic activity tested on various tumor cell lines was very low.
Permanent Link: http://hdl.handle.net/11104/0084271