Astatination of closo-dodecaborate(2-) anion

0185193 - UJF-V 20000367 RIV GB eng C - Conference Paper (international conference)
Orlova, A. - Lebeda, Ondřej - Tolmachev, V. - Lundquist, H. - Carlsson, J. - Sjöberg, S.
Astatination of closo-dodecaborate(2-) anion.
Proceedings of the Conference "Contemporary Boron Chemistry". Cambridge: The Royal Society of Chemistry, 2000 - (Davidson, M.; Hughes, A.; Marder, T.; Wade, K.), s. 144-147
[Conference "Contemporary Boron Chemistry". Durham (GB), 11.07.1999-15.07.1999]
Institutional research plan: CEZ:AV0Z1048901
Subject RIV: BG - Nuclear, Atomic and Molecular Physics, Colliders

Several methods have been reported for the synthesis of dodecahydro-closo-dodecaborate(2-) anion derivatives containing organic side-chains suitable for further conjugation to targeting proteins for use in BNCT. Here we suggest to use boron cages as prosthetic groups for astatination of targeting proteins. The ŕ-emiting nuclide .sub.211 At is probably the best choice for targeted radiotherapy of single tumour cells and microscopic tumour cell clusters, when these are spread in large areas of the body. However, the weak astatine bond to proteins has hampered its use.
Permanent Link: http://hdl.handle.net/11104/0081604