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Cyclic Voltammetry of Biopolymer Heparin at PVC Plasticized Liquid Membrane

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    0181694 - UFCH-W 20030125 RIV NL eng J - Journal Article
    Samec, Zdeněk - Trojánek, Antonín - Langmaier, Jan - Samcová, E.
    Cyclic Voltammetry of Biopolymer Heparin at PVC Plasticized Liquid Membrane.
    Electrochemistry Communications. Roč. 5, - (2003), s. 867-870. ISSN 1388-2481
    R&D Projects: GA ČR GA203/04/0424
    Institutional research plan: CEZ:AV0Z4040901
    Keywords : cyclic voltammetry * PVC plasticized liquit membrane * heparin
    Subject RIV: CG - Electrochemistry
    Impact factor: 2.300, year: 2003

    Cyclic voltammetry is used to study the charge transfer reaction of the biopolymer heparin at the PVC plasticized 1,6-dichlorohexane membrane-solution interface. Several unique feature of the reaction are demonstrated including the apparent diffusion control and the specific interaction of heparin with the cation of the membrane phase, which probably acts as the heparin carrier (ionophore). Voltammetric behaviour corresponds to the interfacial transfer of a mixture of polyanions with a relatively hogh content of polyanions carrying a low charge. Amperometry appears to be a suitable method for the quantification of heparin in various preparations with the sensitivity of ca. 1 U mL-1 (S/N = 3).
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