Acrylonitrile exposure: the effect on p53 and p21WAF1 protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts

0173574 - UEM-P 20023019 RIV NL eng J - Journal Article
Rössner ml., Pavel - Binková, Blanka - Chvátalová, Irena - Šrám, Radim
Acrylonitrile exposure: the effect on p53 and p21WAF1 protein levels in the blood plasma of occupationally exposed workers and in vitro in human diploid lung fibroblasts.
Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. č. 517 (2002), s. 239-250. ISSN 0027-5107
R&D Projects: GA MŽP SI/340/1/97
Institutional research plan: CEZ:AV0Z5039906
Keywords : Acrylonitrile * p53 protein * p21WAF1 protein
Subject RIV: DN - Health Impact of the Environment Quality
Impact factor: 3.158, year: 2002

The study on the effect of ACN exposure on the expression of p53 and p21WAF1 proteins in vitro and in vivo. The study group consisted of 49 subjects exposed to ACN in the petrochemical industry. Subjects living in the same area but not working in this factory were used as controls. No significant differences in either p53, or p21WAF1 levels between the exposed and control groups were found. Also no effect of GSTM1 and GSTT1 genotypes was observed.
Permanent Link: http://hdl.handle.net/11104/0070605