Chemical Probes in Biology. Science at the Interface of Chemistry, Biology and Medicine. NATO Science Series, II. Mathematics, Physics and Chemistry, Vol. 129

0162527 - UIACH-O 20033090 RIV NL eng M - Monography Chapter
Šimánek, V. - Vespalec, Radim - Šedo, A. - Ulrichová, J. - Vičar, J.
Quaternary benzo[c]phenanthridine alkaloids biological activities.Intracellular targets of their action and application in human and veterinary medicine.
Chemical Probes in Biology. Science at the Interface of Chemistry, Biology and Medicine. NATO Science Series, II. Mathematics, Physics and Chemistry, Vol. 129. Dordrecht: Kluwer Academic Publishers, 2003 - (Schneider, M.), s. 245-254. ISBN 1-4020-1769-3
R&D Projects: GA ČR GA203/02/0023
Institutional research plan: CEZ:AV0Z4031919
Keywords : benzo[c]phenanthridine alkaloids * sanguinarine * chelerythrine
Subject RIV: CE - Biochemistry

The article briefly reviewes information on the occurence of of benzo[c]phenanthridine alkaloids (QBA) in plats and on their chemical properties important from the viewpoint of QBA biological and biochemical activities. Than recent results of investigation of authors on QBA are presented: 1. Identification of chemical forms of sanguinarine and cheleryhtrine that complex with mercapto nuclophiles and the determination of stability constants that characterize their binding with human serum albumin;2. Inhibition effects of sanguinarine, cheleryhtrine and fagaronine on DPP-IV-like enzymes isolated from blood plasma and human and rat glinoma cell lines; and 3. QBA role in the genesis of epidemic dropsy syndrome.
Permanent Link: http://hdl.handle.net/11104/0059836