Interactions of sanguinarine and chelerythrine with molecules containing a mercapto group

0162508 - UIACH-O 20033062 RIV GB eng J - Journal Article
Barták, P. - Šimánek, V. - Vlčková, Markéta - Ulrichová, J. - Vespalec, Radim
Interactions of sanguinarine and chelerythrine with molecules containing a mercapto group.
Journal of Physical Organic Chemistry. Roč. 16, č. 10 (2003), s. 803-810. ISSN 0894-3230. E-ISSN 1099-1395
R&D Projects: GA AV ČR IAA4031703; GA ČR GA203/02/0023
Institutional research plan: CEZ:AV0Z4031919
Keywords : capillary electrophoresis * sanguinarine * chelerythrine
Subject RIV: CB - Analytical Chemistry, Separation
Impact factor: 1.182, year: 2003

Interaction of sanguinarine and chelerythrine with compounds containing mercapto group is fast reversible complexation based on non-bonding intermolecular interactions. Only uncharged pseudobase forms of these alkaloids enter in the complexation. A negatively charged group either bonded to the mercapto compound or supplied by the solution participates in the complex formation.Constants for the binding of uncharged sanguinarine with human and bovin serum albumins are 332000+/-8 499 and 141000+/-14 400 l/mol, respectively. For the uncharged form of chelerythrine, the constants are 2 970 000+/-360 000 and 1 380 000+/-2600 l/mol for human and bovine serum albumins, respectively.
Permanent Link: http://hdl.handle.net/11104/0059817