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Two-step processing of human frataxin by mitochondrial processing peptidase
- 1.0153941 - MBU-M 20010005 RIV US eng J - Journal Article
Cavadini, P. - Adamec, Jiří - Taroni, F. - Gakh, O. - Isaya, G.
Two-step processing of human frataxin by mitochondrial processing peptidase.
[Dvoukrokové zpracování lidského frataxinu mitochondriální peptidásou.]
Journal of Biological Chemistry. Roč. 275, č. 52 (2000), s. 41469-41475. ISSN 0021-9258. E-ISSN 1083-351X
Institutional research plan: CEZ:AV0Z5020903
Keywords : eukaryotes * human frataxin
Subject RIV: EE - Microbiology, Virology
Impact factor: 7.368, year: 2000
We showed previously that maturation of the human frataxin precursor (p-fxn) involves two cleavages by the mitochondrial processing peptidase (MPP). This observation was not confirmed by another group, however, who reported only one cleavage. Here, we demonstrate conclusively that MPP cleaves p-fxn in two sequential steps.
Článek se zabývá problematikou dvoukrokového zpracování lidského frataxinu mitochondriální peptidásou
Permanent Link: http://hdl.handle.net/11104/0051433
Number of the records: 1