0142569 - FGU-C 20030176 RIV PL eng J - Journal Article
Filová, Elena - Bačáková, Lucie - Lisá, Věra - Machová, Luďka - Lapčíková, Monika - Kubies, Dana - Proks, Vladimír - Rypáček, František
Vascular smooth muscle cells in cultures on lactide based polymers for potential construction of artificial vessel wall.
Engineering of Biomaterials. Roč. 6, - (2003), s. 9-11. ISSN 1429-7248.
[Konferencja Naukowa "Biomaterialy w medycynie i weterynarii" /13./. Rytro, 09.10.2003-12.10.2003]
R&D Projects: GA AV ČR IAA4050202; GA MŠMT LN00A065
Institutional research plan: CEZ:AV0Z4050913; CEZ:AV0Z5011922
Keywords : tissue engineering * bioactive polymers, RGD * bioartificial vessel wall
Subject RIV: EI - Biotechnology ; Bionics

We focused on adhesion and spreading of vascular smooth muscle cells on lactide- and polyethylenoxide (PEO)-based polymers, materials for potential construction of vascular prostheses. On poly(DL-lactic acid), PDLLA, the number and spreading of initially attached rat aortic VSMC were similar as on standard cell culture plastics. However, the copolymer of PDLLA and PEO, MeO-PEO-b-PDLLA, almost disabled the cell adhesion and spreading. Grafting of GRGDSG peptide (in 5 or 20% concentration) to the copolymer restored the cell adhesion and spreading almost to the values found on PDLLA.
Permanent Link: http://hdl.handle.net/11104/0040270