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Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats
- 1.0142504 - FGU-C 20030128 RIV GB eng J - Journal Article
Zicha, Josef - Pecháňová, O. - Dobešová, Zdenka - Kuneš, Jaroslav
Hypertensive response to chronic NG-nitro-L-arginine methyl ester (L-NAME) treatment is similar in immature and adult Wistar rats.
Clinical science. Roč. 105, č. 4 (2003), s. 483-489. ISSN 0143-5221. E-ISSN 1470-8736
R&D Projects: GA ČR GA305/03/0769; GA MZd NB6682; GA MŠMT LN00A069
Grant - others:VEGA(SK) 2/3185/23; SAV(SK) APVT51-017902
Institutional research plan: CEZ:AV0Z5011922
Keywords : nitric oxide * L-NAME hypertension * age-dependent susceptibility
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 2.117, year: 2003
The same blood pressure rise was demonstrated in young and adult L-NAME treated rats in hich a similar degree of NO synthesis inhibition was disclosed. This suggests that altered NO bioavailability (but not the generally exaggerated reactivity to hypertensive stimuli) is the cause of greater blood pressure response of immature than adult rats to chronic excess salt intake.
Permanent Link: http://hdl.handle.net/11104/0040206
Number of the records: 1