A survey of effects of excessive bromide intake on iodine metabolism in the rat

0142396 - FGU-C 20020121 RIV DE eng C - Conference Paper (international conference)
Pavelka, Stanislav
A survey of effects of excessive bromide intake on iodine metabolism in the rat.
Macro and Trace Elements/Mengen- und Spurenelemente. Leipzig: Schubert Verlag, 2002 - (Anke, M.; Müller, R.; Schäfer, U.; Stoeppler, M.), s. 567-574. ISBN 3-929526-48-4. ISSN 1430-9637.
[Macro and Trace Elements/Mengen- und Spurenelemente. Workshop /21./. Jena (DE), 18.10.2002-19.10.2002]
R&D Projects: GA MZd NJ6109
Institutional research plan: CEZ:AV0Z5011922
Keywords : bromide * iodine metabolism * rat
Subject RIV: ED - Physiology

We studied the effects of an increased bromide intake, at different levels of iodine supply to the organism, on various aspects of iodine metabolism in the rat. A reduction of the food intake and consequently of the body weight gain was observed in rats drinking water with the highest bromide concentration (5 g bromide per liter). An increase in the relative weight of the thyroids and a significant decrease in the 24-h uptake of radioiodide by the thyroids were also found in these animals, especially in those fed a research low-iodine diet. The concentration ratio [I]/[Br] in the thyroids proved to be a very sensitive marker of even negligibly increased bromide intake in the rats.
Permanent Link: http://hdl.handle.net/11104/0040100