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Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation
- 1.0142352 - FGU-C 20020078 RIV US eng J - Journal Article
Koistinaho, M. - Kettunen, M. I. - Goldsteins, G. - Keinänen, R. - Salminen, A. - Ort, Michael - Bureš, Jan - Liu, D. - Kauppinen, R. A. - Higgins, L. S. - Koistinaho, J.
Beta-amyloid precursor protein transgenic mice that harbor diffuse A beta deposits but do not form plaques show increased ischemic vulnerability: role of inflammation.
Proceedings of the National Academy of Sciences of the United States of America. Roč. 99, č. 3 (2002), s. 1610-1615. ISSN 0027-8424. E-ISSN 1091-6490
R&D Projects: GA ČR GA309/00/1656
Institutional research plan: CEZ:AV0Z5011922
Keywords : Beta-amyloid * Alzheimer disease * brain ischemia
Subject RIV: FH - Neurology
Impact factor: 10.701, year: 2002
Transgenic mice overexpressing the 751 isoform of human amyloid precursor protein are more prone to inflammation and ischemia induced brain injury than age-matched wild type mice. It is conceivable that anti-inflammatory therapy may be effective in treatment of Alzheimer disease.
Permanent Link: http://hdl.handle.net/11104/0040058
Number of the records: 1