Modelling the consequences of receptor-G-protein promiscuity

0142321 - FGU-C 20020044 RIV GB eng J - Journal Article
Tuček, Stanislav - Michal, Pavel - Vlachová, Viktorie
Modelling the consequences of receptor-G-protein promiscuity.
Trends in Pharmacological Sciences. Roč. 23, č. 4 (2002), s. 171-176. ISSN 0165-6147. E-ISSN 1873-3735
R&D Projects: GA AV ČR IAA7011910; GA ČR GA309/99/0214
Institutional research plan: CEZ:AV0Z5011922
Keywords : G-protein
Subject RIV: FH - Neurology
Impact factor: 13.277, year: 2002

Many G-protein-coupled receptors interact with more than one type of G protein, giving rise to extreme variability in the effects of receptor activation, depending on, for example, receptor density and desensitization, efficacy of agonists, and availability of specific G proteins. This leads to errors in interpretation of data. To facilitate understanding the consequences of receptor-G-protein promiscuity, we use two simplified models to simulate such consequences. Applied to the regulation of adenylyl cyclase and phosphoinositidase, the models predict seemingly paradoxical situations and explain some phenomena that, at first sight, might seem to require the induction of agonist- specific (G-protein-selective) receptor conformations.
Permanent Link: http://hdl.handle.net/11104/0040027