Mitochondrial ubiquinone (coenzyme Q10): biochemical, functional, medical, and therapeutic aspects in human health and diseases

0142140 - FGU-C 20010194 RIV US eng M - Monography Chapter
Rauchová, Hana - Drahota, Zdeněk - Lenaz, G.
Specific properties of coenzyme Q, function in brown adipose tissue cells.
Mitochondrial ubiquinone (coenzyme Q10): biochemical, functional, medical, and therapeutic aspects in human health and diseases. Arizona: Prominent Press, 2001 - (Ebadi, M.; Marwah, J.; Chopra, R.), s. 217-229. ISBN 0-9668997-3-3
R&D Projects: GA ČR GA303/98/0473
Grant - others:Vědeckotechnická spolupráce mezi Českou republikou a Italskou republikou(XE) Kontakt 2/3
Institutional research plan: CEZ:AV0Z5011922
Keywords : coenzyme Q
Subject RIV: CC - Organic Chemistry

Brown adipose tissue represents a unique model system for demonstration of specific mechanisms participating in the transfer of reducing equivalents between mitochondrial dehydrogenases and coenzyme Q pool. Experimental data indicate that coenzyme Q binding protein is absent in the very active mitochondrial glycerol-3-phosphate enzyme complex. The absence of this protein could be responsible for the capacity of reactive oxygen substances (ROS) production by this enzyme. Glycerol-3-phosphate-dependent production of ROS could be responsible for the induction of apoptosis process and elimination of brown adipose tissue during postnatal development or after a period of hibernation.
Permanent Link: http://hdl.handle.net/11104/0039849