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Assembling a clock for all seasons: are there M and E oscillators in the genes?
- 1.0142126 - FGU-C 20010178 RIV US eng J - Journal Article
Daan, S. - Albrecht, U. - van der Horst, G. T. - Illnerová, Helena - Roenneberg, T. - Wehr, T. A. - Schwartz, W. J.
Assembling a clock for all seasons: are there M and E oscillators in the genes?
Journal of Biological Rhythms. Roč. 16, č. 2 (2001), s. 105-116. ISSN 0748-7304. E-ISSN 1552-4531
R&D Projects: GA ČR GA309/00/1655
Institutional research plan: CEZ:AV0Z5011922
Keywords : evening/morning oscillators * circadian clock genes * pacemaker
Subject RIV: ED - Physiology
Impact factor: 2.695, year: 2001
The hypothesis is advanced that the circadian pacemaker in the mammalian suprachiasmatic nucleus (SCN) is composed at molecular level of a double complex of circadian genes (per1/cry1 and per2/cry2). Each one of these sets would be sufficient for the maintenance of endogenouss rhythmicity and thus constitute an oscillator. The per1/cry1 oscillator is accelerated by light (morning oscillator). and per2/cry2 oscillator is decelerated by light (evening oscillator). These oscillators would give rise to the SCN's neuronal activity in an morning and evening component.
Permanent Link: http://hdl.handle.net/11104/0039835
Number of the records: 1