0142122 - FGU-C 20010173 RIV US eng J - Journal Article
Zicha, Josef - Dobešová, Zdenka - Kuneš, Jaroslav
Relative deficiency of nitric oxide-dependent vasodilation in salt hypertensive Dahl rats: the possible role of superoxide anions.
Journal of Hypertension. Roč. 19, č. 2 (2001), s. 247-254. ISSN 0263-6352. E-ISSN 1473-5598
R&D Projects: GA AV ČR IAA7011805; GA AV ČR IAA7011711; GA MŠMT LN00A069
Institutional research plan: CEZ:AV0Z5011922
Keywords : blood pressure * salt hypertension * Dahl rats
Subject RIV: FA - Cardiovascular Diseases incl. Cardiotharic Surgery
Impact factor: 4.210, year: 2001

The contribution of major vasoactive systems (renin-angiotensin system, sympathetic nervous system and nitric oxide) to blood pressure maintenance and the possible involvement of superoxide anions in the reduced efficiency of NO-dependent vasodilation to counterbalance sympathetic vasoconstriction were studied in salt hypertensive Dahl rats. It was demonstrated that NO system is not able to counterbalance effectively the hyperactivity of sympathetic nervous system in salt hypertensive Dahl rats. The predominance of sympathetic vasoconstriction over NO-dependent vasodilation could partially be explained by enhanced NO inactivation due to augmented superoxide anion formation in hypertensive animals.
Permanent Link: http://hdl.handle.net/11104/0039831