0141991 - FGU-C 20000027 RIV DE eng J - Journal Article
Krajčí, D. - Mareš, Vladislav - Lisá, Věra - Španová, A. - Vorlíček, Jaroslav
Ultrastructure of nuclei of cisplatin-treated C6 glioma cells undergoing apoptosis.
European Journal of Cell Biology. Roč. 79, č. 5 (2000), s. 365-367. ISSN 0171-9335. E-ISSN 1618-1298
R&D Projects: GA AV ČR KSK2011602
Subject RIV: ED - Physiology
Impact factor: 2.801, year: 2000

C6 glioma treated with cisplatin (1.66x 10 5M) ceased dividing by24 h and underwent apoptosis by 72-96 h. The reactive cells wereclassified into 5 types (T-I to V), according to the ultrastructureof nuclei. In T-I cells some nuclear pores were covered with thenovelty structure, the dome-shaped "cap" formed by fine filamentousmaterial. Apoptotic cells (T-IV) apperated in 2 variaties reflectingalternative routes of the cisplatin-triggered apoptosis. Except forthe T-IV and T-V cells, alterations of cytoplasmic organelles, includingmitochondria, were fewer than reported in previous studies on cisplatin.
Permanent Link: http://hdl.handle.net/11104/0039702